Phenotype Image Detail

Image

Caption

Sars1^{tm1.1(KOMP)Vlcg}/Sars1^{tm1.1(KOMP)Vlcg} embryos cannot be recovered at E7.5 (0/28), nor are there excess resorption sites. Homozygous mutants are recovered at E3.5 in expected ratios and appear as normal dying morula. Mutants fail to hatch from the zona with apparent cell death, never reaching a morphological blastocyst stage. RT-PCR indicates robust expression in the oocyte and post-implantation. Knock-in LacZ also shows weak embryonic expression in gastrulation stages. Additional information at websites.umass.edu/jmager/Sars

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Sars1^tm1.1(KOMP)Vlcg	seryl-tRNA synthetase 1; targeted mutation 1.1, Velocigene

Associated Genotypes

Allelic Composition	Genetic Background
Sars1^tm1.1(KOMP)Vlcg/Sars1^tm1.1(KOMP)Vlcg	C57BL/6N-Sars1^tm1.1(KOMP)Vlcg/JMmucd