Phenotype Image Detail

Image

Caption

Scfd1^em1(IMPC)Tcp/Scfd1^em1(IMPC)Tcp embryos cannot be recovered at E7.5 (0/29), however there are excess resorption sites suggesting mutants elicit a decidual response in vivo. Homozygous mutants are recovered at expected ratios at E3.5 and appear as blastocysts. Mutants hatch from the zona and form outgrowths with mixed phenotypes: some do not hatch from the zona or form outgrowths, and some have no apparent inner cell mass and dispersed trophectoderm. RNA-seq data indicates robust maternal and post-2-cell expression. Additional information at websites.umass.edu/jmager/Scfd1

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Scfd1^em1(IMPC)Tcp	Sec1 family domain containing 1; endonuclease-mediated mutation 1, The Centre for Phenogenomics

Associated Genotypes

Allelic Composition	Genetic Background
Scfd1^em1(IMPC)Tcp/Scfd1^em1(IMPC)Tcp	C57BL/6N-Scfd1^em1(IMPC)Tcp/Cmmr