Phenotype Image Detail

Image

Caption

Znhit1^em1(IMPC)J/Znhit1^em1(IMPC)J mutants are able to form blastocysts and hatch in extended culture, but cannot be recovered at E7.5. Analysis at E3.5 showed that mutant embryos have fewer SOX2+ cells and SOX17+cells than wild-type embryos, and NANOG is aberrantly expressed in trophectoderm. RT-PCR showed the robust expression of Znhit1 in wildtype and heterozygous blastocysts, but not mutant embryos. Additional information at websites.umass.edu/jmager/znhit1

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Znhit1^em1(IMPC)J	zinc finger, HIT domain containing 1; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Znhit1^em1(IMPC)J/Znhit1^em1(IMPC)J	C57BL/6NJ-Znhit1^em1(IMPC)J/Mmjax