Phenotype Image Detail

Image

Caption

Exosc1^em1(IMPC)J/Exosc1^em1(IMPC)J embryos can be recovered at E7.5, but they are smaller than their littermates and show many morphological defects, never initiating gastrulation. At E5.5, mutant embryos appear similar in size to control littermates with normal radially symmetrical egg cylinder morphology, albeit the mutant embryonic ectoderm seems slightly disorganized. TUNEL assay reveals TUNEL positive cells specifically in the epiblast of Exosc1 mutants. Exosc1 is ubiquitously expressed throughout embryo development. RT-PCR expression of the 10 murine Exosc genes in various tissues and development stages indicates widespread expression. Additional information at websites.umass.edu/jmager/exosc1

Copyright

This image was contributed directly to MGI. Questions regarding this image or these data should be directed to Dr. Jesse Mager at jmager@umass.edu J:279207

Associated Alleles

Symbol	Name
Exosc1^em1(IMPC)J	exosome component 1; endonuclease-mediated mutation 1, Jackson

Associated Genotypes

Allelic Composition	Genetic Background
Exosc1^em1(IMPC)J/Exosc1^em1(IMPC)J	C57BL/6NJ-Exosc1^em1(IMPC)J/Mmjax