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| Caption | Generation of Sos1-floxed mice. (A) Targeting strategy for tissue-specific deletion of Sos1 by creating the floxed allele Sos1tm1.1Les. Exons (ex) are depicted as black boxes; the neomycin resistance cassette as an open box; Frt sites as filled triangles; and loxP sites as open triangles. The targeting construct used is denoted as the region inside of the circled vertical lines of the TARG-Sos1 schematic. The neo resistance cassette was removed by crossing to Flp-expressing mice in the first generation. Crossing to Cre-expressing mice will remove exon 10 of the Sos1. Probes (prA and prB) and restriction enzyme sites (H, HindIII; N, Nsil; E, EcoRV) uesd for Southern blotting were denoted. | ||||
| Copyright | This image is from Kortum RL, Proc Natl Acad Sci U S A 2011 Jul 26;108(30):12407-12. Copyright 2011 National Academy of Sciences, U.S.A. J:174536 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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