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| Caption | A, targeting strategy. Schematic diagram of the wild-type (WT) Lcn2 (24p3) gene (top), the targeting construct (middle), and the Lcn2tm1Mrgr knock-out (KO) allele (bottom). After homologous recombination, the targeting vector replaces exons 1-5 (indicated by gray boxes) with the phosphoglycerate kinase-neomycin resistance gene (PGK-neo) cassette. The external 5'-flanking probe is indicated, as are the positions of PCR primers for detecting WT (P1 and P2) and mutant KO (P1 and P3) alleles. The position of the external 5'-flanking probe used for Southern blot analysis is indicated, as are the BamHI sites (denoted by the letter B). | ||||
| Copyright | This image is from Liu Z, J Biol Chem 2011 Jun 10;286(23):20606-14 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:173490 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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