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Molecular Image Detail
Image
Caption A, schematic of targeted disruption of Sgms2. The top illustration is a wild-type allele (Sms2); the middle shows the targeting construct with the neomycin-resistant gene (PGK-neo), diphtheria toxin A chain gene (DT-A), and nuclear localization signal-LacZ (NLS-LacZ). The bottom illustration shows the Sgms2tm1Kenw allele mutated by homologous recombination. Closed and open arrowheads are corresponding to the primer position to detect wild-type and knock-out (KO) alleles, respectively.
Copyright This image is from Mitsutake S, J Biol Chem 2011 Aug 12;286(32):28544-55 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:175924
Associated
Alleles
Symbol Name
Sgms2tm1Kenw sphingomyelin synthase 2; targeted mutation 1, Ken Watanabe

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory