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| Caption | Generation of Npc1tm1Mbjg knockin mice harboring two point mutations in NPC1 that abolish cholesterol binding activity. (A) Schematic of the mouse wild-type Npc1 allele and the targeting construct used to generate the Npc1tm1Mbjg (npc1pf) allele by introducting two point mutations (P202;F203 to A202;A203) into exon 5 of Npc1. The targeting vector also contains a loxP-flanked pgkneopA cassette and two copies of the HSV-TK gene as selection markers. The probe used for the Southern blot is denoted by the horizontal filled rectangle labeled "probe". | ||||
| Copyright | This image is from Xie X, Proc Natl Acad Sci U S A 2011 Sep 13;108(37):15330-5. Copyright 2011 National Academy of Sciences, U.S.A. J:176587 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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