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| Caption | (A) Meiotic recombinations in affected mice localized the Zeb1Tw mutation (Tw) to an 814-kb interval between D18nih6 and D18nih42 on proximal chromosome 18. Three genes are located within the Tw critical region. A single nucleotide substitution (c.58+181G>A) was detected in the Zeb1Tw allele in the region of overlapping first introns of Zeb1 and Zeb1os. (B) c.58+181G is evolutionarily conserved and c.58+181G>A disrupts a consensus binding sequence for the Myb family of transcription factors. | ||||
| Copyright | This image is from Kurima K, PLoS Genet 2011 Sep;7(9):e1002307, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177274 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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