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Caption A strategy used for Map3k12 (DLK) gene excision. The construct used for homologous recombination utilized a phosphoglycerate kinase promoter-driven neomycin selection cassette (PGK-NEO) flanked by Flip recombinase target (FRT) sites as well as LoxP sites that surrounded exons 2-5 of Map3k12. This construct was targeted using homologous recombination, and then exons 2-5 of Map3k12 were excised via Cre-mediated recombination in ES cells before blastocyst injection to generate the 5294468 allele.
Copyright This image is from Ghosh AS, J Cell Biol 2011 Sep 5;194(5):751-64, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:176956
Associated
Alleles
Symbol Name
Map3k12tm1.1Lewc mitogen-activated protein kinase kinase kinase 12; targeted mutation 1.1, Joseph W Lewcock
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory