Molecular Image Detail

Image

Caption

Conditional knockout of Cdkal1 in pancreatic beta-cells. (A) The structure of the targeting vector for the generation of conditional Cdkal1 transgenic mice, Cdkal1^tm1.1Tomik/Cdkal1^tm1.1Tomik. Exon 5 of Cdkal1 gene was floxed by LoxP sequence to generate the floxed allele, Cdkal1^tm1.1Tomik. Mating of mice with the Cdkal1^tm1.1Tomik allele to germ-line cre-expressing mice results in the Cdkal1^tm1.2Tomik allele (deleted allele). Alternatively, floxed mice mated with a conditional cre-expressing mouse will also result in the deleted allele.

This image is from Wei FY, J Clin Invest 2011 Sep 1;121(9):3598-608 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:178248

Associated
Alleles

Symbol	Name
Cdkal1^tm1.1Tomik	CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa
Cdkal1^tm1.2Tomik	CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.2, Kazuhito Tomizawa

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