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| Caption | (A) Schematic representation of the wild-type Scrib allele, targeting construct, and mutated Scrib alleles. Excision of the Frt-flanked PGK-Neo cassette in the LoxP-flanked targeting vector was accomplished by crossing Scribfl-Neo mice to Tg(ACTFLPe)9205Dym/0 (Actin-FLPe) mice, producing the Scribtm1.1Phum (Scrib floxed allele (deltaNeo); Scribfl) allele. The insertion of EcoRV and KpnI restriction sites permitted screening for recombinant ES cell clones. Scrib knock-out mice were derived by crossing Scribtm1.1Phum/Scrib+ (Scrib+/fl) mice with a germline Cre-deleter mouse to generate the Scribtm1.2Phum allele (Scrib KO allele). Exons are indicated as boxes and LoxP/FLPe sites as triangles. | ||||||
| Copyright | This image is from Pearson HB, J Clin Invest 2011 Nov 1;121(11):4257-67 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:178461 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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