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| Caption | A, top panel: genomic DNA structure of Cacna1c (Cav1.2) with the relevant restriction enzyme sites; boxes represent exons 44-47 encoding the C terminus of Cacna1c. Middle panel, targeting vector. Neo, neomycin resistance gene; TK, thymidine kinase gene with the loxP sequence (triangles) at both sides. The insertion of the three stop codons after aspartate 1904 is shown. Bottom panel, knock-in locus after homologous recombination and Cre-mediated deletion of resistance markers to generate the Cacna1ctm5.1Hfm allele. The 5' probe; which contains genomic sequence outside of the targeting vector, is depicted as a solid bar. K, KpnI; N, NotI; B, BamHI; C, ClaI; X, XhoI; P, PstI; kb, kilobases. | ||||
| Copyright | This image is from Domes K, J Biol Chem 2011 Sep 30;286(39):33863-71 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:176723 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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