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| Caption | (A) Schematic representation of the mouse GAK locus (top), targeting vector (middle), and targeted locus (bottom), Gaktm1Noj. The coding exons are indicated as black boxes. To delete the kinase domain of GAK, the coding exons 2 (Ex2), 3 (Ex3), and 4 (Ex4) were replaced with a neomycin selection cassette (Neo). The diphtheria toxin A gene (DT-A) was used for negative selection. The arrows indicate the position and orientation of PCR primers for genotyping. The position of Southern blotting probes (probe 5' and 3') are shown as red and blue boxes on the first line, respectively. The restriction fragments of wild-type (WT) and targeted kinase (KO) are shown below. | ||||
| Copyright | This image is from Tabara H, PLoS One 2011;6(10):e26034, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179585 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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