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| Caption | (A) Schematic maps of the targeting construct, wild-type plectin locus (Plec+), and targeted alleles PlecOgna(neor) and Plectm7.1Gwi(PlecOgna) with relevant restriction sites (X, XmaI; H, HindIII). Relevant exons (numbered black boxes), loxP sites (empty triangles), the Ogna mutation (star), mutant allele probes, and sizes of HindIII restriction digests are indicated. The targeting construct, a 15.5 kb-long fragment of the plectin gene starting at exon 15 and finishing in exon 32, carried the Ogna mutation in exon 31 and a loxP-flanked neomycin resistance (neor) cassette (white box) located in the intron between exons 31 and 32. | ||||
| Copyright | This image is from Walko G, PLoS Genet 2011 Dec;7(12):e1002396, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:179812 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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