| Image |
|
||||||
| Caption | (a) The targeted Fbn1 locus. A neomycin selection cassette (PGK-Neo, flanked by FRT sites) was placed in the intron between exons 10 and 11. In addition, loxP sites were introduced before exons 10 and 11 and after exon 12. The neomycin cassette was removed by breeding targeted mice to FLPe mice, generating the Fbn1tm3.1Lysa allele. Cre-mediated recombination of the loxP sites in the germline resulted in deletion of exons 10-12 and generated the Fbn1tm3.2Lysa allele, replicating the human Weill-Marchesani syndrome mutation. | ||||||
| Copyright | This image is from Sengle G, PLoS Genet 2012 Jan;8(1):e1002425, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:181493 | ||||||
|
Associated Alleles |
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 12/10/2024 MGI 6.24 |
|
|
|
||
Analysis Tools