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| Caption | (A) Schematic of the Ror1 gene targeting strategy to generate the floxed Ror1tm1.1Meg and null Ror1tm1.2Meg allele. The Ror1 conditional allele (Ror1f) was generated by flanking exons 3 and 4 of the Ror1 genomic locus with loxP sequences. The Ror1-null allele (Ror1-) was generated by crossing the Ror1f/f mice to the Ella-Cre deleter line. Only the first 54 aa of the Ror1 protein are predicted to be translated from the mRNA expressed from the Ror1tm1.2Meg (Ror1-) allele, followed by a nonsense polypeptide sequence composed of 37 aa before termination of protein synthesis. The red arrows in the targeting scheme denote relative positions of genotyping primers. | ||||||
| Copyright | This image is from Ho HY, Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51. Copyright 2012 National Academy of Sciences, U.S.A. J:182150 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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