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| Caption | (D) Schematic of the Ror2 gene targeting strategy to generate the floxed Ror2tm1.1Meg (Ror2f) allele and the null Ror2tm1.2Meg (Ror-) allele and the predicted mutant Ror2 protein. The Ror2 conditional alelle was generated by flanking exons 3 and 4 of the Ror2 gene with lox2272 sequences. Lox2272, which can undergo Cre-mediated recombination with itself, but not with loxP sequences, was used to avoid potential interchromosomal recombination with the targered Ror1 locus. The Ror2 null allele (Ror2-) was generated by crossing the Ror2f/f mice to the EllA-Cre deleter line. Only the first 59 aa of Ror2 protein are predicted to be translated from the mRNA expressed from the Ror2tm1.2Meg (Ror2-) allele, followed by a nonsense polypeptide sequence composed of 46 aa before termination of protein synthesis. The red arrows denote relative positions of genotyping primers. | ||||||
| Copyright | This image is from Ho HY, Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4044-51. Copyright 2012 National Academy of Sciences, U.S.A. J:182150 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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