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| Caption | Targeting strategy and generation of the Abhd5tm1.1Rze allele. A, homologous recombination of the targeting vector with the wild-type allele resulted in the introduction of a loxP site into intron 3 and a neomycin resistance gene cassette flanked by loxP sites into the downstream sequence of exon 7. Subsequent Cre-recombinase-mediated recombination among the distal loxP sites resulted in the deletion of exons 4-7. The targeted allele was identified by EcoRI (E) restriction digest and hybridization with an external Southern probe (solid bar) revealing an 8.6-kb DNA fragment. | ||||
| Copyright | This image is from Radner FP, J Biol Chem 2010 Mar 5;285(10):7300-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160725 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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