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| Caption | (B) Targeting strategy to create a point mutation in exon 10 of the mouse Gne gene. To make the targeted allele, the wild-type Gne locus was replaced with a targeting vector, which contained a point mutation in exon 10, a neo cassette and a DT-A cassette, by homologous recombination. The neo cassette, flanked by two loxP sites, was deleted by a Cre-expressing adenoviral vector to make the point mutation allele, Gnetm1.1Masn. Neo, neomycinresistance gene; DT-A, diphtheria toxin A fragment; triangles, loxP sites; open boxes with numbers, exons; closed boxes, exon 10 containing the point mutation. | ||||
| Copyright | This image is from Ito M, PLoS One 2012;7(1):e29873, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:184315 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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