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| Caption | Targeting scheme for generation of Huwe1 (arf-bp1) conditional knock-out mice. A, gene targeting scheme of mouse Huwe1. The wild-type allele represents the genomic region surrounding the exon 11, whereas P indicates restriction sites for PstI (wild-type allele). Targeting vector contains exon 11 with flanking loxP sites and 7-kb 5' homology and 4 kb 3' homology (targeting vector). After homologous recombination, the conditional knock-out allele, Huwe1tm1Wgu, is identified based on altered restriction fragments of PstI (conditional allele). Upon expression of Cre recombinase, the conditional knock-out allele can be converted to knock-out (exon 11-deleted) allele. | ||||
| Copyright | This image is from Kon N, J Biol Chem 2012 Feb 10;287(7):5102-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:182446 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/02/2024 MGI 6.13 |
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