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Image
Caption (A) Schematic representation of the Pik3c3 conditional knockout strategy. LoxP sites flank exon 4 of the Pik3c3 gene. In the diagram, the targeting vector is the schematic for the Pik3c3tm1a(EUCOMM)Wtsi allele and the flox allele is the schematic for the Pik3c3tm1c(EUCOMM)Wtsi allele. Expression of the Cre recombinase results in excision of exon 4 and a frame shift causing a deletion of 755 of the 887 amino acids of Pik3c3.
Copyright This image is from Jaber N, Proc Natl Acad Sci U S A 2012 Feb 7;109(6):2003-8. Copyright 2012 National Academy of Sciences, U.S.A. J:182628
Associated
Alleles
Symbol Name
Pik3c3tm1a(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1a, Wellcome Trust Sanger Institute
Pik3c3tm1a(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1a, Wellcome Trust Sanger Institute
Pik3c3tm1c(EUCOMM)Wtsi phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1c, Wellcome Trust Sanger Institute
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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10/29/2024
MGI 6.24 		The Jackson Laboratory