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| Caption | A, schematic representation of Trio conditional knock-out strategy. The 11.5-kb genomic DNA fragment containing Trio exons 22-25 was subcloned from 129 BAC. The first loxP site (red arrowheads) was targeted downstream of exon 25. This generates the floxed Triotm1Mzhu allele. Mice containing the floxed allele can be crossed with mice expressing Cre recombinase to remove the floxed region. The probes used for Southern blot analysis are shown in solid blue bars, and the locations of PCR primers (a-d) are for screening homologous recombination (green arrows). | ||||
| Copyright | This image is from Peng YJ, J Biol Chem 2010 Aug 6;285(32):24834-44 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165902 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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