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Caption A, gene targeting strategy for generation of Prkab2tm1Grst and Prkab2tm1.1Grst alleles. The Prkab2tm1Grst allele (targeted allele) was made by inserting a loxP upstream of exon 2, and a floxed neo cassette downstream of exon 4. Cre-mediated recombination removes exon 2 through 4 and the neo cassette, generating the Prkab2tm1.1Grst allele (deleted allele).
Copyright This image is from Steinberg GR, J Biol Chem 2010 Nov 26;285(48):37198-209 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:167339
Associated
Alleles
Symbol Name
Prkab2tm1.1Grst protein kinase, AMP-activated, beta 2 non-catalytic subunit; targeted mutation 1.1, Gregory R Steinberg
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11/19/2024
MGI 6.24 		The Jackson Laboratory