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| Caption | (A) Vangl2 gene function was disrupted by genetically modifying the wild-type allele to contain two LoxP sequences flanking exon 4. A neomycin-resistance selection cassette (NeoR) with FRT sites was included for selecting recombinant clones. Regions of homologous recombination between the wild-type and targeted gene are indicated by light gray shading. Following Cre and FlpE-mediated recombination events, the targeted allele is reduced to the Vangl2tm1.2Mdea (vangl2deltaTMs) knockout allele. The position of KpnI (K), HindIII (H), and XbaI (X) restriction endonuclease sites and the location of probes (59, 39 and NeoR) used for Southern blot analysis are indicated. | ||||
| Copyright | This image is from Yin H, PLoS One 2012;7(2):e31988, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185311 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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