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| Caption | A, C1THF synthase consists of three domains: the MTHFD/MTHFC catalytic domain, the MTHFD/MTHFC NADP-NADP binding domain, and the FTHFS catalytic domain. The amino acid residues forming each domain are indicated. The Mthfd1 gene consists of 28 exons. The gene trap vector inserted into intron 26-27 of the Mthfd1 gene, generating the Mthfd1Gt(XB175)Byg allele. PCR priming sites are indicated by arrows. B, the gene trap vector cassette in the Mthfd1 gene is detected as a 320-bp PCR product, whereas the wild-type allele is detected as a 553-bp PCR product. | ||||
| Copyright | This image is from MacFarlane AJ, J Biol Chem 2009 Jan 16;284(3):1533-9 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:146083 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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