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| Caption | Pxmp2 disruption strategy and verification of gene inactivation. (A) Schematic representation of the mouse Pxmp2 targeting vector and structure of the locus following gene targeting which generates the Pxmp2tm1Jkh allele. The directions of the transcription of Pxmp2 and PoleI are shown by angled arrows. The first exon of PoleI is denoted as a black box and the exons of Pxmp2 are presented as numbered boxes. Relevant restriction sites are shown: S = SacI, E = EcoRI, X = XbaI and B = BamHI. The arrows for lacZ (beta-galactosidase gene) and neo (neomycin phosphotransferase gene) indicate the direction of transcription of the corresponding genes. The locations of a 5' external probe (Probe) for Southern analysis and primers used for PCR genotyping (small arrows) are shown. | ||||
| Copyright | This image is from Rokka A, PLoS ONE 2009;4(4):e5090, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148171 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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