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| Caption | (A) The constructs that were employed are illustrated. In the CC10-tTs-hGH construct, the Clara Cell 10-kD protein promoter (Scgb1a1; CC10 Promoter) was used to drive the tetracycline-regulated transcriptional silencer (tTS). In the CC10-rtTA-hGH construct, the Scgb1a1 (CC10) promoter drives the reverse tetracycline-controlled transcriptional activator (rtTA). The tetO-CMV-YKL-40-beta-globin construct contains multimers of the tet operator, a minimal CMV promoter, and a human CHI3L1 (YKL-40) cDNA. All three constructs were simultaneously injected into fertilized eggs to generate leak-free triple transgenic mice. | ||||
| Copyright | This image is from Lee CG, J Exp Med 2009 May 11;206(5):1149-66, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:148490 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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