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Caption | Targeting strategy for the Itgb1tm5.1Ref (hpmKIlox) allele. (A) Partial map of the Itgb1 (beta1A) wild-type (wt), the hpm knock-in allele before (hpmKIneo-tk+) and after Cre-mediated deletion of the floxed neo-tk cassette (hpmKIlox). External probes used for Southern blotting after BamHI digest and genotyping PCR primers are indicated. Cyto-cDNA, a wt 141 bp cDNA fragment coding for the complete cytoplasmic domain of the Itgb1 gene including the endogenous stop codon; E15cyto, endogenous sequence of exon 15 encoding for the membrane proximal part of the beta1 integrin cytoplasmic tail; filled boxes, exons; D, exon D; neo, neomycin resistance gene; tk, thymidine kinase gene; triangles, loxP sites; pA, polyadenylation signal. | ||||
Copyright | This image is from Piwko-Czuchra A, PLoS ONE 2009;4(5):e5488, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:148885 | ||||
Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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