Molecular Image Detail

Image

Caption

(A) Schematic representations of (i) a portion of the mouse NuMA gene including exons 16-25 and EcoRI restriction sites, (ii) the exon 22 targeting vector showing the neomycin resistance (Neo) and diphtheria toxin (DT) cassettes and placement of loxP and FRT sites, (iii) the structure of the correctly targeted allele with the introduced SacII restriction site and locations of genotyping primers (Numa1^tm1Dwc), (iv) the conditional allele (flox) produced by Flp-enhanced recombinase-mediated recombination of FRT sites flanking Neo (Numa1^tm1.1Dwc), and (v) the deletion allele (delta22) produced by Cre recombination of loxP sites surrounding exon 22 (Numa1^tm1.2Dwc). Red bars indicated exon 22.

This image is from Silk AD, J Cell Biol 2009 Mar 9;184(5):677-90, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:146214

Associated
Alleles

Symbol	Name
Numa1^tm1.1Dwc	nuclear mitotic apparatus protein 1; targeted mutation 1.1, Don W Cleveland
Numa1^tm1.2Dwc	nuclear mitotic apparatus protein 1; targeted mutation 1.2, Don W Cleveland
Numa1^tm1Dwc	nuclear mitotic apparatus protein 1; targeted mutation 1, Don W Cleveland

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