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| Caption | Generation of the Tyk2tm3.1Biat allele. B. Scheme of the murine Tyk2 locus from exons 9-24 (black boxes). The point mutations introduced in exon 20 resulting in the amino acid exchange K>E and the introduction of the BspTI restriction endonuclease site are depicted. The neomycin resistance cassette (neor, white box) flanked by loxP sites (black triangles) was inserted into the intron sequence between exons 21 and 22. The lower scheme shows the targeted locus with the restriction sites important for Southern blot analysis. Note that after germline transmission the neor cassette was excised to leave a single loxP site in the mutated allele. | ||||
| Copyright | This image is from Prchal-Murphy M, PLoS One 2012;7(6):e39141, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:187818 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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