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| Caption | Strategy for the generation of Lmx1btm2(cre/ERT2)Rjo (Lmx1b-IREScreERT2) and Lmx1btm3(cre/ERT2)Rjo (Lmx1bPM-IREScreERT2) alleles. (a) Schematic representation of the targeting strategy. An IREScreERT2-floxed PGK-neo cassette was inserted into the 3' UTR of Lmx1b genomic locus. For the Lmx1btm3(cre/ERT2)Rjo allele, a point mutation (C to A) was also inserted into exon 5 which encodes a portion of the homeodomain. This mutation results in a single amino acid substitution (N246K) that renders this allele null for Lmx1b. The 5' external probe is shown as an orange rectangle. B, BamHI; Sm, SmaI; RV, EcoRV; H, HindIII; B, BamHI; Bs, BssHII; *, point mutation; triangles, loxP sites; black rectangles, exon encoding domains. | ||||||
| Copyright | This image is from Qiu Q, Genesis 2009 Apr;47(4):224-33, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:149241 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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