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| Caption | Generation of the Fgfr2tm3Ewj allele. (A) The Fgfr2 targeting construct contains exons IIIa, IIIb, IIIc, and exon 10, which codes for the transmembrane domain (TM) of the gene, a neo cassette flanked by loxP sequences (open arrows), and the 1181A>G (based on nucleotide sequence NM_010207.2 and results in Y394C protein mutation) (*) in exon 10. Screening for recombinant clones was done by Southern blot analysis using restriction enzymes HindIII (H) or DrdI (D) and probes indicated (-). Other restriction enzyme sites noted are SacI (S), BsaHI (B), XcmI (X), and EcoNI (E). PCR primers (F, Fn, R; arrows) used for genotyping are shown. | ||||
| Copyright | This image is from Wang Y, J Clin Invest 2012 Jun 1;122(6):2153-64 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190491 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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