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Caption | Generation of the Map2k7tm1Pngr allele. Targeted gene disruption of murine Map2k7. (B) partial restriction map of murine genomic Map2k7 sequence and construction of targeting vector 2. Targeting vector 2 (B) contains a hygromycin resistance gene (Hyg) plus three loxP sequences (triangles) and a neomycin resistance gene (Neo), respectively. The 14 exons of Map2k7 are shown as boxes, and MAP2K7-coding regions as filled boxes. The genomic Map2k7 3'-flanking probe used for Southern blotting is indicated as gray boxes. The predicted structure of the targeted allele is shown as neo. Restriction enzymes used for the vector construction (H, HindIII, and HincII) and genomic Southern blotting (XbaI) are indicated by arrows. | ||||
Copyright | This image is from Kishimoto H, J Biol Chem 2003 May 9;278(19):16595-601 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:83279 | ||||
Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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