Molecular Image Detail

Image

Caption

Targeting constructs used to create the Dkc1^tm2Pjma and Dkc1^tm3Pjma alleles. The diagram shows the Dkc1 gene with the exons represented as black rectangles. The arrows indicate the direction of transcription of the Dkc1 and adjacent Mpp1 genes. Targeting constructs consisted of exons 10-15 of the Dkc1 gene with a IRES-NEO element in the 3' UTR and point mutations in exons 11 (A353V) or 12 (G402E). The Dkc1^tm2Pjma allele has the A353V mutation in exon 11 and the Dkc1^tm3Pjma allele has the G402E mutation in exon 12. Probes and restriction enzymes used to analyze the targeted alleles in ES cells and mice are shown. B, BamHI; Bs, BspHI; H, HindIII; E, EcoRI.

This image is from He J, Genesis 2009 Jun;47(6):366-73, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:149894

Associated
Alleles

Symbol	Name
Dkc1^tm2Pjma	dyskeratosis congenita 1, dyskerin; targeted mutation 2, Philip J Mason
Dkc1^tm3Pjma	dyskeratosis congenita 1, dyskerin; targeted mutation 3, Philip J Mason

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