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Molecular Image Detail
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Caption Creation of the Pank2tm1.1Suja allele. A selection cassette containing cDNA encoding thymidine kinase (TK) and neomycin resistance (NEO) was inserted into the intron between exons 2 (Ex2) and 3 (Ex3) of the Pank2 gene. The cassette was flanked by loxP (c) sites. A third loxP site was inserted between exons 3 (Ex3) and 4 (Ex4). Cre-recombinase-mediated deletion of the DNA between the outermost loxP sites resulted in a knockout (KO) allele which lacked Ex3 and lacked the selection cassette. Locations of the primers (arrows) for PCR genotyping are shown. PCR products and sizes are indicated (bars), and B indicates the presence of a BamHI site.
Copyright This image is from Garcia M, PLoS One 2012;7(7):e40871, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189609
Associated
Alleles
Symbol Name
Pank2tm1.1Suja pantothenate kinase 2; targeted mutation 1.1, Suzanne Jackowski

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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory