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| Caption | Schematic representation of the Atp7a gene-targeting strategy. Exons 8-13 of the wild-type and recombinant Atp7a locus are shown. The targeting construct included LoxP sites (black triangles) that flanked exon 11 and a PGKneo gene cassette flanked by FRT sites (grey triangles). The PGKneo gene cassette was removed by crossbreeding with the ACT-FLPe deleter strain expressing FLP1 recombinase to generate mice with the desired floxed allele, Atp7atm1.1Mjp (Atp7afl). The exon 11-deleted Atp7a allele (Deleted) is depicted following excision by Cre recombinase, which was detected using PCR primers P1 and P2. | ||||
| Copyright | This image is from Wang Y, PLoS One 2012;7(8):e43039, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:189931 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/17/2024 MGI 6.24 |
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