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| Caption | Generation of the Vsx2tm1.1Itl and Vsx2tm1.1Eml alleles. (B) Schematic representation of the targeting strategy. The R200Q and R227W mutations (asterisk) were introduced into exon 4 and the ACN cassette was cloned into intron 3 of Vsx2. These elements were then placed into the pTK1TK2 targeting vector. After homologous recombination, R200Q-ACN and R227W-ACN chimeric mice were generated. The ACN cassette was deleted by Cre recombination in the male germline generating the Vsx2tm1.1Itl (R200Q) and Vsx2tm1.1Eml (R227W) alleles. Chimeric males were crossed with wild-type females to generate germline transmitted R200Q and R227W heterozygous mice. | ||||||
| Copyright | This image is from Zou C, PLoS Genet 2012 Sep;8(9):e1002924, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:190452 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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