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| Caption | Generation of the conditional Six1tm2.1Mair (Six1flox) and delta Six1tm2.2Mair (Six1delta) alleles (A) Schematic representation of the wild-type Six1 locus, with the restriction sites used in the present study. The 3.5-kb 5' and 2.1-kb 3' homologous fragments are indicated by two-headed arrows. The Six1-loxP targeting fragment is shown with loxP sites as blue arrowheads. The 5' lox site is integrated in the 5' untranslated region of Six1 first exon at the Sac2 restriction site. The targeted Six1 mutant alleles after Flip and Cre excisions are depicted below. Schematic representations are not drawn to scale. | ||||||
| Copyright | This image is from Le Grand F, J Cell Biol 2012 Sep 3;198(5):815-32, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190460 | ||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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