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| Caption | Engineering of the Dp(17Nfkbil1-Or2h1)1Cogr [Dp(MHC-I)] duplication. A) MICER targeting vectors MHPP188d21 and MHPN390j16 are indicated. The 5' Hprt and 3' Hprt parts of the Hprt gene and genes for selectable markers (puro)-puromycin and (neo)-neomycin are outlined. Relevant restirction sites are indicated by X (XbaI), S (SpeI), N (NcoI). Diagnostic probes and restriction fragments expected from restriction digestion analysis of wild-type and of the targeted alleles are indicated. B) Chromosomal structure of the duplication [Dp(MHC-I)] alleles after Cre recombination. Relevant restriction sites and diagnostic restriction fragments are indicated. | ||||
| Copyright | This image is from Ermakova O, Mamm Genome 2012 Aug;23(7-8):443-53 and is displayed with the permission of Springer Science + Business Media, Inc., New York who owns the copyright. J:190754 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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