Molecular Image Detail

Image

Caption

Generation of non-polyalanine repeat expansion mutations (NPARM) Phox2b^tm1.1Heno and Phox2b^tm2.1Heno knock-in alleles. (B) Schematics showing the gene-targeting strategy. Gray boxes indicate exons of the Phox2b gene. Red boxes show human genomic fragments spanning from the deletion mutations to the aberrant stop codon due to the shift in the open reading frame (ORF). A floxed (white triangles) Tn5-neo cassette was removed in vivo by Cre recombination. Bars depict the location of the probe for Southern blot analysis and PCR primers for screening the recombined ES clones.

This image is from Nagashimada M, J Clin Invest 2012 Sep 4;122(9):3145-58 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:190742

Associated
Alleles

Symbol	Name
Phox2b^tm1.1Heno	paired-like homeobox 2b; targeted mutation 1.1, Hideki Enomoto
Phox2b^tm2.1Heno	paired-like homeobox 2b; targeted mutation 2.1, Hideki Enomoto

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24