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| Caption | Generation of the Limk2Gt(OST80053)Lex allele. (A) Retroviral gene trap vector VICTR48 (EU676804) was used to produce OmniBank clone OST80053, which contains an insertion within intron 12 of the Limk2 gene. The Limk2 transcript variants 1-3 (v1-3) represent protein isoforms a-c, respectively, according to current NCBI Reference Sequence annotation for accessions NM_010718.3, NM_173053.1, and NM_001034030.1 (intron/exon numbering based on transcript v1). This mutation would be expected to truncate the Limk2 gene product within the kinase domain following coding exon 12, disrupting all reported transcript variants of the Limk2 gene. Open boxes denote untranslated exons, filled boxes denote coding exons. Exons that code for the LIM domains are shown in orange, those that code for the PDZ domain are shown in blue, and those that code for the kinase domain are shown in red. LTR, viral long terminal repeat; SA, splice acceptor sequence; neo, neomycin phosphotransferase gene; pA, polyadenylation sequence; Pgk, phosphoglycerate kinase-1 promoter; Btk-SD, Bruton's tyrosine kinase splice donor sequence. *The Limk2 v3 transcript is elsewhere referred to as Limk2t or tLimk2. | ||||
| Copyright | This image is from Rice DS, PLoS One 2012;7(10):e47168, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192231 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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