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| Caption | Smarce1 (Baf57) allelic series produced by a single gene-trap vector. The domain structure of Smarce1 is depicted at the top, where the N-terminal 23-residue proline-rich region (P) is encoded by Exons 2 to 4. Smarce1 translation normally starts at the ATG in exon 2, but exon 4 (and exon 5) also contains an ATG that is in frame with the remaining sequence. The targeting vector contains a pair of Flippase recognition target (FRT) sites (red dots) and a pair of LoxP sites (triangles) flanking the gene-trap cassette. During homologous recombination, crossing over at the left arm can happen downstream or upstream of the 5' Lox P site (red vertical lines 1 and 2 flanking the 5' Lox P site), generating the Smarce1tm1Tich (57deltaR) and the intermediate Smarce1tm2Tich (57Int) alleles, respectively, the latter convertible to Smarce1tm2.1Tich (57F), where exons 2 and 3 are floxed. DT, diphtheria toxin expression cassette; HMG, high mobility group; NHRLI, a domain rich in Asp, His, Leu and Ile; NLS, nuclear localization signal. | ||||||||
| Copyright | This image is from Chaiyachati BH, BMC Biol 2013;10():96, an open-access article, licensee BioMed Central Ltd. J:194195 | ||||||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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