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| Caption | Generation of the Cited2tm3.1Bha (Cited2T166) allele. (A) Targeting strategy by homologous recombination. The T to N change was introduced by site directed mutagenesis into the orthologous residue in the mouse sequence. The structure of the wild-type allele, targeting vector, targeted allele, and its structure after FLP mediated recombination are shown. The open reading frame (ORF, blue arrow) is entirely contained within exon 2 (exons indicated by grey rectangles). The targeting vector has an frt-PGK-NeoR-frt selection cassette downstream of exon 2 followed by a DTA (diphtheria toxin) cassette. | ||||
| Copyright | This image is from Chen CM, PLoS One 2012;7(10):e46256, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192202 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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