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| Caption | The Pomctm2Low allele contains an insertion of a neomycin resistance cassette (neo), flanked by loxP sites, interrupting Pomc neuronal enhancer activity. Red oval, neuronal Pomc enhancer 1 (nPE1); asterisk, deletion of nPE2 (18); gray oval, Pomc promoter/pituitary enhancer; black rectangles, Pomc exons; arc and pit arrows, arcuate and pituitary Pomc transcription, respectively; X, inhibition of arcuate Pomc transcription. | ||||
| Copyright | This image is from Bumaschny VF, J Clin Invest 2012 Nov 1;122(11):4203-12 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194013 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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