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| Caption | Generation of the Ctsktm1.1Rbar allele. (A) To generate the targeting construct pG3NEOBLoxP-2, the expression cassette for the neomycin resistance gene (NEO) flanked by loxP sites (large arrowheads) was inserted in reverse orientation between the EcoRI (ERI) and the BamHI (BHI) sites in intron 5 of the Ctsk gene. Successful targeting of the Ctsk locus resulted in insertion of the 3 loxP sites and the NEO gene into the Ctsk gene. Cre recombinase can be used to conditionally sequentially remove the sequences between the loxP sites including exon 5 and the NEO cassette, leaving only one loxP site in the locus. | ||||
| Copyright | This image is from Lotinun S, J Clin Invest 2013 Jan 16;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194492 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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