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| Caption | Generation of the Gnai2tm2.1Lbi allele. (A) Targeting strategy. Wild-type (WT) allele: depicts the region of the WT Gnai2 gene containing the targeted exons 2, 3, and 4 (blue) used to construct the targeting vector. Targeting vector: depicts the portion of the targeting vector used to target the Gnai2 locus. Floxed allele, Gnai2tm2.1Lbi: depicts the structure of the targeted allele after Cre-mediated excision of the PGK-Neo cassette. Deleted allele: depicts the structure of the disrupted allele from which exons 2, 3, and 4 have been removed by the action of Cre recombinase. The position of key restriction endonuclease sites and the location of genotyping primers A and B are indicated. Rectangles, exons included in targeting vector; heavy red line, intronic sequence included in the targeting vector; PGK-Neo, neomycin selection cassette; dt, diptheria toxin selection cassette. | ||||
| Copyright | This image is from Plummer NW, Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21366-71. Copyright 2012 National Academy of Sciences, U.S.A. J:193170 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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