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| Caption | Disruption of the murine Fbx15 gene. A, embryonic stem cells containing a gene-trapped (GT) Fbx15 allele were used to generate the Fbxl5Gt(OST386421)Lex allele. A trapping vector containing a promoter-less neomycin (Neo) resistance cassette flanked by a splicing acceptor (SA) site and a polyadenylation signal sequence (pA) was inserted 3' of Fbx15 exon 2. Utilization of the SA site generates a truncated FBXL5 mRNA transcript competent for Neo expression. The trapping vector also contains the first exon of the Bruton's tyrosine kinase (Btk) gene flanked by the PGK promoter sequence and a splicing donor site (SD). The resultant chimeric fusion transcript was used to generate a sequence tag of the trapped gene by 3' RACE. | ||||
| Copyright | This image is from Ruiz JC, J Biol Chem 2013 Jan 4;288(1):552-60 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193752 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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