Molecular Image Detail

Image

Caption

Generation of Clic1^tm1Breit and Clic1^tm1.1Breit alleles. Schematic representation of the wild-type (WT) Clic1 locus (a), targeting vector pTKClic1loxp3Neo (b), targeted Clic1^tm1Breit (Clic1^FN) allele (c), and Clic1^tm1.1Breit (Clic1^-) allele (d). Clic1 exons 1 to 7 are shown as filled black boxes. 5' and 3' genomic DNA and introns are shown as solid black lines. NeoR cassette is shown as a gray filled box and three loxP sites are shown as gray triangles. Probe 1 used for Southern blot analysis is depicted by solid lines. Diagnostic restriction sites are depicted: E, EcoRV, N, NcoI, Ns, Nsi I, and S, SacII. The translation start site is depicted by an arrow. The flag epitope is shown as a white flag.

This image is from Qiu MR, Genesis 2010 Feb;48(2):127-36, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:158394

Associated
Alleles

Symbol	Name
Clic1^tm1.1Breit	chloride intracellular channel 1; targeted mutation 1.1, Samuel Breit
Clic1^tm1Breit	chloride intracellular channel 1; targeted mutation 1, Samuel Breit

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