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| Caption | Generation of the Sp2tm1Sus (Sp2lzn) allele. A) Schematic representation of the Sp2 protein structure, the wild-type Sp2 allele, the targeting vector and the targeted Sp2lzn allele. The Sp-box (Sp), two glutamine-rich domains (Q-rich),the btd-box (btd) and the three zinc fingers (ZnF) of the Sp2 protein are indicated. Connecting lines with the corresponding murine Sp2 gene region indicate the derivation of N-terminal parts of the Sp2 protein. The Sp-box and two glutamine-rich regions are encoded by exon 3. In the targeted Sp2 locus, exon 3 and the IRES-lacZ-neo cassette are floxed (black arrowheads). White arrowheads depict PCR primer locations (P1, P2 and P3). S, SacI sites. | ||||
| Copyright | This image is from Baur F, PLoS One 2010;5(3):e9587, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158671 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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